The Genetics of Substance Dependence

نویسندگان
چکیده

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The genetics of substance dependence.

A large segment of the population suffers from addiction to alcohol, smoking, or illicit drugs. Not only do substance abuse and addiction pose a threat to health, but the consequences of addiction also impose a social and economic burden on families, communities, and nations. Genome-wide linkage and association studies have been used for addiction research with varying degrees of success. The m...

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Drug-dependence disorders (we focus here on cocaine, opioid, and nicotine dependence) are genetically influenced. Risk genes have been located based primarily on genetic linkage studies, and identified primarily based on genetic association studies. In this article we review salient results from linkage, association, and genome-wide association study methodologies, and discuss future prospects ...

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ژورنال

عنوان ژورنال: Annual Review of Genomics and Human Genetics

سال: 2012

ISSN: 1527-8204,1545-293X

DOI: 10.1146/annurev-genom-090711-163844